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Anti-Proteinase 3 (ANCA) – Serum Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that target a protein found in white blood cells, called proteinase 3. It helps identify a type of autoimmune condition called systemic vasculitis.

Quick summary

["This test may help diagnose or monitor certain inflammatory diseases affecting blood vessels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69957-9
Short code
Proteinase3 IgG Ser Ql IA
Synonyms
Proteinase3 IgG Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like joint pain, skin rashes, kidney problems, or unexplained fevers. It’s also used to check for conditions like Wegener’s granulomatosis or microscopic polyangiitis, which involve inflammation in small blood vessels.

What to Expect Before the Test

No special preparation is needed. You’ll likely have a simple blood draw from a vein in your arm. If you’re on blood thinners or have a history of bleeding disorders, let your provider know before the test.

What the Test Results Mean

Positive results suggest the presence of ANCA antibodies, which can indicate an autoimmune response targeting blood vessels. However, false positives can occur, so results are often reviewed with clinical symptoms and other tests.

Common Conditions Linked to ANCA Test Results

Elevated levels are most strongly linked to vasculitis but may also appear in other inflammatory or infectious conditions. Your provider will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

ANCA (Anti-Neutrophil Cytoplasmic Antibody) Test

Frequently asked questions

How often will I need this test?
Your provider may repeat the test if symptoms worsen, improve, or if you’re being monitored for treatment response. Frequency depends on your condition and treatment plan.
What if my results are positive but I don’t have symptoms?
Positive results don’t always mean you have an active disease. Your provider will assess symptoms, other test results, and medical history to determine next steps, which may include further evaluation or observation.
Can diet or supplements affect this test?
Diet or supplements typically do not interfere with ANCA testing. However, if you’re on medications (e.g., steroids, immunosuppressants), let your provider know as they may influence results or treatment decisions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy