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Urine Protein-to-Creatinine Ratio

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of protein relative to creatinine in a urine sample to help assess kidney function and detect urinary protein loss.

Quick summary

["This urine test helps detect and monitor abnormal protein loss through the kidneys."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87434-7
Short code
Protein + creat Pnl Ur
Synonyms
Protein + creat Pnl Ur
Category
kidney
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

The urine protein-to-creatinine ratio compares the amount of protein in your urine with the amount of creatinine. Creatinine is a waste product made by the muscles, and adjusting for it helps account for differences in urine concentration.

Why might I need this test?

This test may be used to screen for kidney disease, evaluate people with diabetes or high blood pressure, and monitor conditions that can damage the kidneys. It can also help identify increased urinary protein, sometimes called albuminuria or proteinuria.

How is the test performed?

A urine sample is collected and tested to measure its protein and creatinine levels. The laboratory then calculates the protein-to-creatinine ratio. Your clinician will interpret the result along with your other laboratory findings, symptoms, and medical history.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. Collection timing and whether an overnight or 24-hour collection is required depend on the specific order. Tell your clinician if you have a urinary tract infection, exercise heavily, or have recently had blood in your urine, as these factors may affect the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Protein/Creatinine Ratio

Frequently asked questions

Does this test show how much protein is in my urine?
It estimates the amount of protein relative to creatinine, which helps account for how concentrated or dilute the urine is. Other tests may be needed to identify the specific type of protein.
Is a urine protein-to-creatinine ratio the same as a 24-hour urine protein test?
No. A ratio is usually calculated from a single urine sample, while a 24-hour urine test measures total protein excreted over a full day. Your clinician will determine which collection method is appropriate.
Can exercise or a urinary tract infection affect the result?
Yes. Strenuous exercise, fever, urinary infection, and blood in the urine may temporarily increase urinary protein. Your clinician may recommend repeat testing when these conditions are present.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy