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Protein Electrophoresis (Serum/Plasma) with 24-Hour Urine Collection for Proteinuria Screening

Published: August 9, 2026Updated: August 17, 2026

This test measures protein patterns in your blood and checks for unusual amounts of protein in your urine over 24 hours, which may indicate kidney issues or other health conditions.

Quick summary

["Helps identify protein imbalances that could signal kidney disease or other disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
81231-3
Short code
Prot Elph Pnl 24h Ur Elph
Synonyms
Prot Elph Pnl 24h Ur Elph
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
7.35
Ref high
7.45
Critical range
7.2 N/A – 7.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The blood test evaluates the distribution of different protein types (such as albumin, globulins, and other fractions) using electrophoresis. This helps identify abnormalities in protein composition that may not be detected by general protein measurements alone.

Why Your Urine Sample Was Collected

The 24-hour urine collection assesses total protein excretion, which can reveal chronic kidney damage or conditions like nephrotic syndrome by showing whether protein is being lost in urine beyond normal levels.

How Results May Affect Your Care

Abnormal results may prompt further testing, such as kidney function tests or specialized urine analysis, to determine the underlying cause of protein loss or abnormal protein patterns.

Common Causes of Abnormal Results

Protein electrophoresis in blood and urine may show abnormal patterns due to kidney diseases (e.g., glomerulonephritis), liver disorders, multiple myeloma, or certain infections.

Reference range

NCBI: pH 7.35-7.45N/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis Profile

Frequently asked questions

Why might I need this test?
Your doctor may order this test if you have symptoms like swelling, frequent urination, or if they suspect kidney disease, liver problems, or other conditions affecting protein metabolism.
What does a normal result mean?
A normal result means your blood proteins are balanced and your urine contains typical protein levels, suggesting no immediate kidney or systemic issues. However, follow-up may still be needed if symptoms persist.
Can I eat or drink anything before this test?
For the blood draw, you can eat normally. For the urine collection, follow your doctor’s instructions carefully, as fasting or dietary restrictions may apply to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy