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Protein Mass Concentration in Urine (24-hour collection)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your urine over a 24-hour period. Protein in urine can indicate kidney problems or other health conditions.

Quick summary

["Protein in urine may signal kidney damage or other health concerns that need attention."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108021-7
Short code
Prot Msmt Ur
Synonyms
Prot Msmt Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect kidney disease, such as nephrotic syndrome, glomerulonephritis, or other conditions affecting how your kidneys filter waste and fluids. It can also help monitor kidney function in people with diabetes, high blood pressure, or other chronic health issues.

What to Expect Before the Test

You’ll need to collect all urine for a full 24-hour period, typically starting after midnight on one day and ending the same time the next day. Drink plenty of fluids but avoid foods or medications that might affect protein levels (like certain supplements or high-protein diets).

What the Results Mean

Higher-than-normal protein levels in urine can mean your kidneys aren’t working properly, allowing proteins to leak into your urine. Lower-than-normal levels may suggest dehydration or other factors. Results are interpreted by your doctor based on your medical history and other tests.

Common Causes of Abnormal Results

Proteinuria (protein in urine) can result from kidney disease, infections, high blood pressure, diabetes, or certain medications. Some conditions, like pregnancy or exercise, may cause temporary protein loss.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

How often should I get this test?
Your doctor will determine how often you need this test based on your health condition. For example, people with kidney disease may need it more frequently, while others with stable conditions might only need it occasionally.
What does a 'normal' result mean?
A 'normal' result means your urine protein levels are within the expected range for your age and health. However, even a normal result doesn’t guarantee your kidneys are healthy—your doctor will consider other factors, like symptoms and lab results, to make a full assessment.
Can I drink alcohol before this test?
Alcohol may not significantly affect protein levels in urine, but it can impact overall health and kidney function. Follow your doctor’s advice—some may recommend avoiding alcohol for a few days before testing to reduce potential interference.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy