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Protein Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, helping identify abnormalities in protein distribution that may signal conditions like multiple myeloma, liver disease, or kidney problems.

Quick summary

["This test helps doctors check for unusual protein patterns that could indicate health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27822-6
Short code
Prot S Act/Nor PPP
Synonyms
Prot S Act/Nor PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does the Test Measure?

Protein electrophoresis separates blood proteins into fractions (e.g., albumin, globulins) using an electric field. This helps detect abnormal protein levels or patterns, which may point to diseases affecting the liver, kidneys, or blood cells.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, swelling, or if they suspect conditions like multiple myeloma, amyloidosis, or chronic liver/kidney disease.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.

Common Conditions Detected

This test can help diagnose or monitor conditions such as multiple myeloma (cancer of plasma cells), chronic liver disease, kidney disease, or certain autoimmune disorders by identifying abnormal protein bands or levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis

Frequently asked questions

What does a protein electrophoresis test show?
It shows the distribution of different proteins in your blood, including albumin, globulins, and sometimes unusual spikes or bands that may represent abnormal proteins or conditions like multiple myeloma.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your doctor will explain the findings and next steps during your follow-up visit.
Can I eat or drink before this test?
Check with your doctor or lab for specific instructions, but generally, no special diet is required unless noted. Drink water as usual unless advised otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy