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Protein Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, helping identify abnormalities in protein distribution that may signal conditions like kidney disease, liver issues, or certain cancers.

Quick summary

["This test helps diagnose and monitor conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31102-7
Short code
Prot S Act/Nor PPP Chro
Synonyms
Prot S Act/Nor PPP Chro
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
chromo
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to investigate symptoms such as swelling, unexplained weight loss, fatigue, or changes in kidney/liver function. It can also be used to screen for conditions like multiple myeloma, amyloidosis, or chronic kidney disease.

What Does the Test Involve?

A small blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum or plasma, and proteins are analyzed using electrophoresis, a method that separates proteins based on size and charge.

What Are Common Findings?

Electrophoresis can reveal abnormal bands or shifts in protein distribution. For example, high levels of a specific protein (like Bence Jones proteins) may indicate multiple myeloma, while altered albumin or globulin levels could suggest liver or kidney problems.

Preparation for the Test

No special preparation is needed, but avoid heavy meals or excessive alcohol before the test. If you’re on blood thinners, inform your provider before the draw.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Protein Electrophoresis

Frequently asked questions

How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Follow-up with your healthcare provider to discuss findings and next steps.
What does it mean if my results are abnormal?
Abnormal results may prompt further testing, such as additional protein analysis, imaging, or biopsies, to determine the underlying cause. Your provider will explain how these results fit into your overall health picture.
Can I eat or drink before this test?
Yes, you can eat and drink normally before the test unless instructed otherwise. Avoid heavy meals or alcohol to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy