Serum Protein Electrophoresis (Qualitative)
This test measures the different types of proteins in your blood using electrophoresis, a method that separates proteins based on size and charge.
["Electrophoresis helps identify abnormal protein patterns that may signal conditions like multiple myeloma or other blood disorders."]
Key facts at a glance
- LOINC
- 27823-4
- Short code
- Prot S Ag Act/Nor PPP IA
- Synonyms
- Prot S Ag Act/Nor PPP IA
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Proteins Are Measured?
Electrophoresis splits blood proteins into distinct bands, including albumin (the most abundant protein), globulins (which include antibodies and other immune proteins), and sometimes markers for abnormal proteins like Bence Jones proteins in multiple myeloma.
How Is This Test Performed?
A small blood sample is drawn, and the serum is separated and placed in an electric field. Proteins migrate toward the opposite charge, creating visible bands that are analyzed for quantity and pattern.
When Might You Need This Test?
Your doctor may order this test if you have symptoms like unexplained weight loss, fatigue, bone pain, or if tests suggest an abnormal protein profile, such as in conditions like multiple myeloma or chronic inflammation.
What Does the Result Mean?
Results show the distribution of proteins, with abnormal patterns indicating potential disorders. For example, a spike in certain globulins may suggest an immune-related condition, while unusual bands could point to a malignancy.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is crucial for diagnosing and monitoring conditions affecting protein balance in the blood, such as plasma cell dyscrasias (e.g., multiple myeloma), liver disease, or autoimmune disorders. It helps track disease progression or response to treatment by comparing protein patterns over time.
Short name
Protein Electrophoresis
Frequently asked questions
Why was I asked to fast before this test?
What should I expect during the blood draw?
Can I take my medications before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy