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Protein Free Albumin-to-Globulin Protein Ratio (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the ratio of albumin to globulin proteins in your blood, which can help assess protein balance and potential health conditions.

Quick summary

["This ratio helps identify protein-related imbalances that may signal underlying health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4677-1
Short code
Prot S Free Ag PPP IA-aCnc
Synonyms
Prot S Free Ag PPP IA-aCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is the Albumin-to-Globulin Ratio Testing For?

Albumin and globulin are two main types of proteins found in your blood. Albumin helps maintain fluid balance and carries nutrients, while globulins support immune function and transport substances. The ratio compares their relative amounts, which can reflect overall protein health, inflammation, or nutritional status.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have symptoms like swelling, unexplained weight changes, chronic fatigue, or signs of liver/kidney disease. It can also help monitor conditions like malnutrition, infections, or autoimmune disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is processed to separate albumin and globulin proteins, and their concentrations are measured using a specialized lab technique.

What Does a High or Low Ratio Mean?

A higher ratio may suggest low albumin (possibly due to liver/kidney disease or malnutrition), while a lower ratio could indicate excess globulins (linked to inflammation or immune disorders). Neither result alone is diagnostic—results are interpreted alongside clinical findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Albumin-to-globulin ratio

Frequently asked questions

How often will I need this test?
This test is often ordered as a one-time screening or during follow-up for chronic conditions. Frequency depends on your health status and doctor’s recommendations—typically not routine unless you have symptoms or risk factors.
What should I do if my results are abnormal?
Abnormal results may prompt further testing (e.g., liver/kidney function panels) or discussions about diet, medications, or underlying conditions. Always follow your doctor’s guidance for next steps.
Can diet or lifestyle changes affect this test?
Yes—protein intake, hydration, and chronic illnesses (e.g., liver disease) can influence protein levels. Avoid alcohol 48 hours before testing and inform your doctor about medications or recent illnesses.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy