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Protein Free Plasma/Plasma Protein Concentration (Total)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein present in your plasma, excluding proteins that are bound to other substances. Proteins are essential for many bodily functions, including blood clotting, immune response, and maintaining fluid balance.

Quick summary

["Assessing your plasma protein levels helps identify potential issues with protein synthesis, kidney function, or fluid balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5889-1
Short code
Prot S Free PPP-aCnc
Synonyms
Prot S Free PPP-aCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Plasma proteins play critical roles in your body’s health. Low levels might suggest conditions like malnutrition, liver disease, or kidney problems, while abnormal results could indicate fluid imbalances or other health concerns. This test helps healthcare providers monitor overall protein status and guide treatment plans.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw, where a small amount of plasma is collected. If you’re on blood thinners, let your provider know before the test.

Common Conditions Monitored

This test is often used to evaluate conditions like protein-losing syndromes, liver disease, kidney dysfunction, or malnutrition. It may also help assess fluid retention or dehydration in certain cases.

What Your Results Might Mean

Results are compared to standard ranges for your age and health status. Very low levels may signal protein deficiency, while very high levels could indicate dehydration or certain inflammatory conditions. Always discuss results with your provider for personalized interpretation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein in Plasma

Frequently asked questions

How often do I need this test?
The frequency depends on your health status. Your healthcare provider may recommend this test periodically if you have conditions like kidney disease, liver issues, or chronic malnutrition. Regular monitoring helps track changes over time.
Can diet affect this test?
Yes, diet can influence protein levels. High-protein diets may increase protein concentration, while low-protein diets could lower it. Avoid extreme dietary changes before testing to get accurate results.
What if my results are out of range?
If your results are abnormal, your provider will review them with you. They may recommend further testing, adjustments to your treatment plan, or additional evaluations to determine the cause and next steps.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy