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: Protein, Serum or Plasma, Mass Concentration Measurement

Published: August 9, 2026Updated: August 16, 2026

: This test measures the total amount of protein in a sample of serum or plasma, helping give a general picture of your nutritional and fluid status.

Quick summary

[": A serum protein measurement is a general indicator of overall protein balance in the body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2884-5
Short code
Prot Smn-mCnc
Synonyms
Prot Smn-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What This Test Measures

: Your blood contains many different proteins that perform jobs like carrying nutrients, fighting infection, and maintaining fluid balance. This test measures the combined mass of all these proteins in the liquid part of your blood (serum or plasma) and reports it as a mass concentration.

: Why It Is Ordered

: A clinician may order this test as part of a general health panel or when monitoring conditions that affect protein levels, such as liver or kidney problems, nutritional concerns, or unusual swelling. It is often interpreted alongside other tests such as albumin.

: How the Sample Is Collected

: A small blood sample is drawn from a vein, usually in your arm. Serum or plasma is then separated from the blood cells in the laboratory so the protein can be measured. No special preparation is typically needed unless your clinician says otherwise.

: Understanding Your Results

: Results are reported as a concentration, but a single value is rarely interpreted alone. Your clinician considers the result together with your symptoms, other lab tests, and your overall health. If your level is outside the expected range, they may recommend additional testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: Serum Protein

Frequently asked questions

: Do I need to fast before this test?
: Fasting is usually not required for a total protein measurement, but follow any instructions your clinician or laboratory gives you, since other tests drawn at the same time may require fasting.
: What can cause an abnormal protein level?
: Levels can be affected by dehydration, poor nutrition, liver or kidney disease, inflammation, and other conditions. Your clinician will interpret the result along with your other findings.
: Is this the same as an albumin test?
: No. Total protein measures all proteins combined, while albumin measures one specific protein. They are often ordered and interpreted together.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy