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Protein Electrophoresis, Serum (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood serum using electrophoresis, a technique that separates proteins based on size and charge.

Quick summary

["Helps identify abnormal protein patterns that may signal conditions like multiple myeloma, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35322-7
Short code
Prot sp2 p sincalide Fld-mCnc
Synonyms
Prot sp2 p sincalide Fld-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Proteins Does This Test Measure?

Electrophoresis splits blood proteins into fractions, including albumin, globulins (such as immunoglobulins), and other smaller/mid-sized proteins. Abnormal bands or shifts may indicate underlying health concerns.

Why Might You Need This Test?

Your doctor may order this test to diagnose or monitor conditions like multiple myeloma, liver disease, kidney disease, or certain autoimmune disorders. It can also help assess protein loss in urine (e.g., nephrotic syndrome).

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The serum is then separated and analyzed for protein distribution.

What Are Common Results?

Results show protein bands on an electrophoresis gel. Normal patterns have distinct bands, while abnormal patterns (e.g., extra bands, smearing) may require further testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for detecting conditions affecting protein synthesis, breakdown, or retention. For example, a spike in monoclonal proteins may signal multiple myeloma, while low albumin could indicate liver or kidney disease. Always discuss results with your healthcare provider.

Short name

Protein Electrophoresis

Frequently asked questions

Why do I need this test if I don’t have symptoms?
Your doctor may recommend it as part of a routine checkup, to monitor a known condition, or to investigate unexplained symptoms like fatigue, swelling, or unexplained weight changes.
What if my results show abnormal protein patterns?
Abnormal results often prompt follow-up tests, such as a quantitative protein test (e.g., serum protein electrophoresis) or urine tests. Your doctor will guide next steps based on your symptoms and medical history.
Can diet affect this test?
Dietary changes may indirectly influence protein levels (e.g., high protein intake could temporarily alter patterns), but your doctor will consider your overall health before interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy