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Protein Total Serum Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood serum, which helps assess overall protein levels and identify potential imbalances.

Quick summary

["Your blood protein levels can indicate kidney function, nutritional status, or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5892-5
Short code
Prot S PPP-aCnc
Synonyms
Prot S PPP-aCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein is essential for many bodily functions, including maintaining fluid balance, supporting immune responses, and transporting nutrients. Low or high protein levels may signal underlying health issues like kidney disease, liver problems, or malnutrition.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your doctor recommends it. Wear a loose shirt for easy access to your arm.

What the Results Mean

Results are typically reported as a total mass concentration (e.g., grams per deciliter). While reference ranges vary by lab, abnormal results may prompt further testing to explore causes like dehydration, protein loss, or organ dysfunction.

Common Causes of Abnormal Results

Low protein levels may occur due to kidney disease, severe infections, or poor nutrition. High levels could indicate dehydration, liver disease, or conditions like multiple myeloma. Your doctor will discuss findings in relation to your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Serum Protein

Frequently asked questions

What might cause my protein levels to be different from the reference range?
Several factors can influence protein levels, including diet, hydration status, chronic illnesses, or medications. Recent illness, stress, or even pregnancy can temporarily alter results. If your results are outside the expected range, your doctor may order additional tests to investigate.
Will I need to do anything after the test?
No special follow-up is required unless your doctor notes an abnormality. If you have questions about your results, schedule a follow-up visit with your healthcare provider to discuss next steps.
Is this test painful or uncomfortable?
The test involves a small needle inserted into your arm for a few minutes to draw blood. Most people experience minimal discomfort, and the area may feel sore briefly afterward. You can resume normal activities immediately.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy