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Protein Electrophoresis, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, separated by size and charge. It helps identify conditions affecting protein distribution, such as infections, kidney disease, or certain cancers.

Quick summary

["This test helps doctors check for abnormal protein patterns that may signal underlying health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16113-3
Short code
PR Tiss-Imp
Synonyms
PR Tiss-Imp
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect conditions like multiple myeloma, liver disease, kidney problems, or chronic infections. It can also be used to monitor treatment progress for certain diseases.

How the Test Works

A small blood sample is taken and sent to a lab. The serum is placed on a gel and separated by electric current, creating bands that represent different protein types. A machine then analyzes these bands to determine protein concentrations.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves a fasting sample. Wear comfortable clothing and arrange for someone to drive you home if you’re taking blood thinners.

What to Expect During the Test

A healthcare provider will insert a needle into your arm to draw blood. You may feel a slight pinch, but the process is quick. The test itself takes only a few minutes, and you can resume normal activities afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Protein Electrophoresis

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss the findings with you during your follow-up visit.
What does it mean if my protein electrophoresis shows unusual bands?
Unusual bands or patterns may suggest conditions like multiple myeloma (extra protein spikes), liver disease (altered albumin/globulin ratios), or chronic infections (increased acute-phase proteins). Your doctor will interpret the results in the context of your medical history and symptoms.
Can I eat or drink before this test?
No special diet is required for this test, but if your doctor specifies fasting for another reason (e.g., glucose monitoring), follow their instructions. Otherwise, you can eat and drink normally.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy