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Protein Mass Concentration in Serum (Total Protein)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and globulins. Proteins are essential for maintaining fluid balance, supporting immune function, and transporting nutrients.

Quick summary

["Total protein levels help assess hydration, liver function, and overall protein status in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10861-3
Short code
PR Tiss-mCnt
Synonyms
PR Tiss-mCnt
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like dehydration, liver disease, kidney problems, or nutritional deficiencies. It can also help diagnose or monitor certain diseases, such as infections, inflammation, or protein-losing syndromes.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours if your blood is drawn early in the morning. Wear comfortable clothing and plan to stay near the testing site for about 15 minutes while the blood is drawn.

What Happens During the Test?

A healthcare professional will insert a small needle into a vein in your arm to collect blood. You may feel a slight pinch, but the procedure is quick. The blood sample is then sent to a lab for analysis.

What Are Possible Results and Their Meaning?

Results are typically reported as a total protein concentration in grams per deciliter (g/dL). Lower than expected levels may suggest malnutrition, liver disease, or kidney problems, while higher levels could indicate dehydration or conditions like multiple myeloma.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Serum Protein

Frequently asked questions

What does my total protein level tell me about my health?
A total protein test helps identify imbalances that could indicate underlying health issues. For example, low protein levels might point to poor nutrition, liver or kidney disease, or excessive protein loss through urine (e.g., nephrotic syndrome). High levels could suggest dehydration or conditions like multiple myeloma, where abnormal protein production occurs.
How often should I get this test?
The frequency depends on your medical condition and healthcare provider’s recommendations. Some people may need this test annually or more often if they have chronic health issues like liver disease or kidney problems.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. Eating a balanced diet rich in protein may help maintain normal levels, while poor nutrition or excessive protein loss can lower them. Your provider may advise dietary adjustments if needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy