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Serum/plasma substance concentration for a specific protein (e.g., albumin, globulin, or other protein marker) measured by immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of certain proteins in your blood, which can help doctors understand how well your organs are working or identify potential health issues.

Quick summary

["Protein levels in your blood can signal kidney, liver, or immune system function and help diagnose conditions like proteinuria or hypoalbuminemia."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
19197-3
Short code
PSA SerPl-sCnc
Synonyms
PSA SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
4
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84153
SNOMED
39392002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect problems with your kidneys, liver, immune system, or overall protein balance. It could also be part of routine check-ups or monitoring for conditions like heart disease, infections, or certain cancers.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it involves drawing blood from your vein. If you’re taking certain medications, let your doctor know.

How the Test Is Performed

A healthcare provider will collect a blood sample from a vein in your arm using a needle. The blood is then sent to a lab for analysis using an immunoassay method to detect and measure specific proteins.

What the Results Mean

Results will show the concentration of proteins in your blood. Abnormally high or low levels may indicate underlying health concerns, but your doctor will interpret the results in the context of your medical history and symptoms.

Reference range

Normal: <4.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High protein levels might suggest dehydration, inflammation, or certain cancers, while low levels could signal kidney disease, liver problems, malnutrition, or immune disorders. Your doctor will use these findings to guide treatment or further testing.

Short name

Protein Level (Serum/Plasma)

Frequently asked questions

What causes protein levels to be abnormal?
Protein levels can be affected by conditions like kidney disease (which may lead to proteinuria), liver disease, infections, or certain medications. Lifestyle factors, such as diet or hydration status, can also influence results.
How often should I get this test?
Your doctor will determine how often you need this test based on your health needs. Some people may need it once a year, while others may require more frequent monitoring if they have chronic conditions.
Can diet or exercise affect protein test results?
Yes, diet (especially protein intake) and hydration can influence blood protein levels. Avoiding certain foods or staying well-hydrated may help ensure more accurate results, but follow your doctor’s instructions for preparation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy