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Psilocin/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures psilocin relative to creatinine, helping assess psilocybin exposure while accounting for differences in urine concentration.

Quick summary

["A detectable result may indicate recent exposure to psilocybin or a related substance, but it should be interpreted by your healthcare professional."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
101796-1
Short code
Psilocin/Creat Ur Cfm
Synonyms
Psilocin/Creat Ur Cfm
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures psilocin, a substance associated with psilocybin, in urine and compares its amount with the amount of creatinine. Creatinine is used as a reference because urine can vary considerably in concentration.

Why might I need this test?

This test may be ordered as part of substance-use monitoring, medication or drug screening, or evaluation of possible psilocybin exposure. It may also be used to check results that require confirmation.

How is the test performed?

A urine sample is collected and analyzed in the laboratory. The result is reported as a ratio of psilocin to creatinine rather than as a urine concentration alone.

How do I prepare for the test?

Follow the laboratory's collection instructions and tell the healthcare professional about any medicines, supplements, or other substances you have used. Do not stop prescribed medicines unless your clinician advises you to do so.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A detectable psilocin result may indicate recent exposure to psilocybin or a related substance, although timing and the amount taken cannot be determined from this test alone. The result can be influenced by urine concentration, collection timing, and other exposures. An unexpected positive result should be reviewed with a healthcare professional and may need confirmation with another laboratory method.

Short name

Urine psilocin-to-creatinine ratio

Frequently asked questions

Does this test show exactly when psilocybin was used?
No. Psilocin can remain detectable for a limited period, but the result cannot establish the exact dose, time, or route of exposure.
Why is creatinine included in the result?
Creatinine helps account for how concentrated or dilute the urine sample is. This makes results from different samples easier to compare.
What if the result is unexpectedly positive?
Review your medicines, supplements, and other substance exposures with your clinician. The laboratory or healthcare professional may recommend repeat or confirmatory testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy