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Serum or Plasma Immunoassay for Anti-Glomerular Basement Membrane Antibodies (Anti-GBM)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that target a protein found in the kidneys’ filtering units. It helps diagnose a rare but serious condition called Goodpasture syndrome, which can damage both kidneys and lungs.

Quick summary

["This test may help identify a serious autoimmune condition affecting kidney and lung function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77214-5
Short code
PSP IgA Ser IA-aCnc
Synonyms
PSP IgA Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like sudden kidney failure, blood in your urine, or unexplained lung problems. It’s also used in cases where kidney biopsy results suggest Goodpasture syndrome.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. If you’re on blood thinners, let your provider know before the test.

What the Test Results Mean

Positive results indicate a high likelihood of Goodpasture syndrome. Negative results suggest other conditions may be causing your symptoms, but further testing may still be needed.

Common Symptoms Linked to This Test

Symptoms like severe back pain, coughing up blood, or sudden kidney function decline may prompt this test. Early diagnosis is critical for managing kidney and lung damage.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Anti-GBM antibodies attack a protein in kidney and lung tissues, leading to rapid inflammation and damage. Detecting these antibodies early allows for prompt treatment to prevent permanent organ damage, such as kidney failure or lung scarring.

Short name

Anti-GBM Antibody Test

Frequently asked questions

How is this test different from other kidney-related blood tests?
Unlike general kidney function tests (e.g., creatinine or blood urea nitrogen), this test specifically targets antibodies that cause direct tissue damage in kidneys and lungs. It’s not a routine screening test but is critical for diagnosing specific autoimmune conditions.
Can lifestyle changes affect this test result?
No, this test measures antibodies in your blood, which are produced by your immune system. While certain medications (like immunosuppressants) may influence antibody levels, lifestyle factors like diet or exercise do not directly impact this test.
What if my test results are positive but I don’t have obvious symptoms?
A positive result suggests a high risk of Goodpasture syndrome, even if symptoms aren’t immediately apparent. Your provider will likely recommend close monitoring, possibly including kidney function tests, lung imaging, or further antibody testing to guide treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy