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Prothrombin Complex Activity (Serum/Plasma) with INR Calculation

Published: August 9, 2026Updated: August 16, 2026

This test measures how well your blood can clot by evaluating the activity of certain clotting factors (prothrombin and related proteins) in your blood. It also calculates the International Normalized Ratio (INR), a standardized way to compare results across labs.

Quick summary

["Helps assess bleeding risks and monitor treatment for blood clotting disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97026-9
Short code
PS-prothrom cmplx IgG IgM Pnl SerPl
Synonyms
PS-prothrom cmplx IgG IgM Pnl SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your body needs a balanced mix of clotting factors to stop bleeding when you cut or injure yourself. This test checks how effectively these factors work together to form a clot. An abnormal result may indicate conditions like vitamin K deficiency, liver disease, or blood clotting disorders.

How the Test Works

A small blood sample is taken and mixed with a special reagent. The time it takes for a clot to form is measured. The INR is then calculated by comparing your result to a standard value, accounting for differences in lab methods.

Common Conditions Monitored

This test is often used to monitor patients on blood thinners (like warfarin) to prevent excessive bleeding or clots. It’s also helpful in diagnosing or managing conditions like liver disease, bleeding disorders, or inherited clotting problems.

What to Expect Before the Test

No special preparation is needed, but inform your doctor if you’re taking blood thinners, have recent surgery, or have any bleeding disorders. Avoid aspirin or other NSAIDs for a few days before testing if advised by your provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Prothrombin Function Test

Frequently asked questions

What does an abnormal result mean?
A prolonged prothrombin time (longer clot time) or elevated INR may suggest bleeding risks, liver disease, or vitamin K deficiency. A shortened time or low INR could indicate unusually fast clotting, which may raise concerns about clotting disorders or medications that thin the blood.
Can I get this test at home?
No, this test requires a blood draw in a clinical setting. Your doctor will schedule it during a regular office visit or lab appointment.
How long will results take?
Results are typically available within 1–2 business days, depending on your lab. Your doctor will discuss them with you during your follow-up visit.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy