Prothrombin Complex Activity (Serum/Plasma) with INR Calculation
This test measures how well your blood can clot by evaluating the activity of certain clotting factors (prothrombin and related proteins) in your blood. It also calculates the International Normalized Ratio (INR), a standardized way to compare results across labs.
["Helps assess bleeding risks and monitor treatment for blood clotting disorders."]
Key facts at a glance
- LOINC
- 97026-9
- Short code
- PS-prothrom cmplx IgG IgM Pnl SerPl
- Synonyms
- PS-prothrom cmplx IgG IgM Pnl SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Your body needs a balanced mix of clotting factors to stop bleeding when you cut or injure yourself. This test checks how effectively these factors work together to form a clot. An abnormal result may indicate conditions like vitamin K deficiency, liver disease, or blood clotting disorders.
How the Test Works
A small blood sample is taken and mixed with a special reagent. The time it takes for a clot to form is measured. The INR is then calculated by comparing your result to a standard value, accounting for differences in lab methods.
Common Conditions Monitored
This test is often used to monitor patients on blood thinners (like warfarin) to prevent excessive bleeding or clots. It’s also helpful in diagnosing or managing conditions like liver disease, bleeding disorders, or inherited clotting problems.
What to Expect Before the Test
No special preparation is needed, but inform your doctor if you’re taking blood thinners, have recent surgery, or have any bleeding disorders. Avoid aspirin or other NSAIDs for a few days before testing if advised by your provider.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Prothrombin Function Test
Frequently asked questions
What does an abnormal result mean?
Can I get this test at home?
How long will results take?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy