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Plasma Creatinine Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood plasma. It helps assess kidney function by reflecting how well your kidneys filter blood.

Quick summary

["A creatinine test helps check kidney health and diagnose kidney disease early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33356-7
Short code
PT 1h NP Cont PPP
Synonyms
PT 1h NP Cont PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag-tissue-factor-induced-factor-substitution-h-post-incubation-after-addition-of-normal-plasma
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor kidney function, especially if you have symptoms like swelling, fatigue, or changes in urine output. It’s also used before certain procedures, to check for kidney problems in people with diabetes, high blood pressure, or other health conditions that can affect kidneys.

What to Expect Before the Test

No special preparation is needed unless instructed by your doctor. You may be asked to fast for 8–12 hours before the test if it’s part of a larger panel, but a simple creatinine test can be done anytime. Drink plenty of water the day before if you’re dehydrated.

What Happens During the Test?

A small blood sample is drawn from a vein, usually in your arm. The process takes a few minutes, and you may feel slight discomfort, but it’s quick and not painful. The blood is sent to a lab for analysis.

What the Results Mean

Higher than expected levels may suggest kidney problems, while lower levels could indicate dehydration or muscle breakdown. Your results will be compared to a reference range specific to your age, sex, and health status.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: plasma

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key marker for kidney function because they reflect how well your kidneys filter waste products from blood. Elevated levels often signal impaired kidney function, which can lead to kidney disease, fluid buildup, or other complications. Regular monitoring helps manage conditions like diabetes or hypertension that increase kidney risk.

Short name

Creatinine (Plasma)

Frequently asked questions

What causes creatinine levels to change?
Creatinine levels can rise if your kidneys aren’t working well, or if you’re dehydrated, have muscle problems, or take certain medications. They may also drop if you’re overhydrated or have a sudden drop in muscle mass.
How often should I get this test?
Your doctor will determine how often you need this test based on your health. If you have kidney disease, diabetes, or high blood pressure, you may need it more frequently to monitor progress or adjust treatment.
Can diet affect creatinine levels?
Dietary changes like eating more protein or drinking less water can temporarily affect creatinine levels, but your doctor will consider overall health factors, not just diet, when interpreting results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy