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Serum or plasma concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential kidney or liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33880-6
Short code
PT 2h NP PPP Cont
Synonyms
PT 2h NP PPP Cont
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag-tissue-factor-induced-factor-substitution-h-post-incubation-after-addition-of-normal-plasma
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Total Protein Matters in Your Health

Total protein is a key marker for how well your body maintains protein balance. Low levels may suggest conditions like malnutrition, kidney disease, or liver problems, while high levels could indicate dehydration, inflammation, or certain cancers. It’s often checked alongside albumin to better understand protein status.

What Can Affect Your Results?

Several factors can influence total protein levels, including diet (high-protein vs. low-protein intake), hydration status, recent blood loss, or certain medications. For example, dehydration can raise protein levels, while severe illness or kidney issues may lower them.

When You Might Need This Test

Your doctor may order a total protein test to evaluate kidney function, liver health, nutritional status, or to diagnose conditions like multiple myeloma, chronic kidney disease, or severe infections.

What to Expect During the Test

A simple blood draw is used to collect the sample. The test is quick and typically done in a lab. No special preparation is needed, but fasting may be advised in some cases for related tests.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: plasma

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How does total protein relate to my overall health?
Total protein helps identify imbalances that may signal underlying health issues, such as protein-losing conditions (e.g., kidney disease) or conditions that alter protein synthesis (e.g., liver disease). It’s also used as a baseline for monitoring chronic conditions.
What if my total protein is outside of normal ranges?
If your results are abnormal, your doctor will discuss potential causes with you, such as dietary factors, medical conditions, or medications. Follow-up tests or additional evaluations may be recommended to pinpoint the issue.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. High-protein diets may temporarily raise protein concentrations, while low-protein diets or malnutrition can lower them. Your doctor may ask about your diet if results seem unusual.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy