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Serum or plasma concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein status and kidney function.

Quick summary

["Total protein levels can signal kidney health or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33885-5
Short code
PT 2h p 1:4 NP PPP
Synonyms
PT 2h p 1:4 NP PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag-tissue-factor-induced-factor-substitution-h-post-incubation-after-addition-of-normal-plasma
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done? Your healthcare provider may order this test to check how well your body is working, to look for signs of illness, or to monitor a condition you already have.

Doctors may order a total protein test to check for conditions like kidney disease, liver problems, malnutrition, or certain infections. It can also help monitor protein loss due to conditions like kidney failure or excessive sweating.

What Does the Result Mean? Your results show whether your values fall within the expected range. Results that are higher or lower than normal may point to a health issue that needs further evaluation by your provider.

Results are typically reported as a range, but they can vary based on factors like age, sex, and overall health. Low protein levels may indicate poor nutrition or organ dysfunction, while very high levels could suggest conditions like multiple myeloma or severe dehydration.

Common Conditions Affecting Results: Certain conditions, such as infections, dehydration, liver or kidney problems, and some long-term illnesses, can affect your results, as can medicines, supplements, and what you ate recently.

Low protein levels might be linked to malnutrition, kidney disease, or liver disorders. High levels could signal dehydration, inflammation, or certain blood disorders.

Sample Collection and Preparation: A trained staff member will collect your sample, usually a small amount of blood from a vein in your arm. Follow any special instructions from your provider, such as fasting, before your appointment.

This test uses blood drawn from a vein, usually in your arm. The blood is separated into serum (liquid part after clotting) or plasma (liquid part before clotting) for testing.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: plasma

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

Total protein levels are important for diagnosing and managing conditions affecting protein metabolism, kidney function, or overall health. Abnormal results may prompt further testing to identify underlying causes.
Most results are ready within 1 to 3 business days, although some specialized tests can take a week or longer. Your healthcare provider's office will contact you to discuss the results once they are available.
Results are usually available within 1 to 3 business days, depending on your lab’s processing schedule.
That depends on the type of test. Some tests require fasting for 8 to 12 hours beforehand, while others allow you to eat and drink normally. Follow the instructions from your healthcare provider, and plain water is usually allowed.
You may eat and drink normally before the test unless instructed otherwise by your healthcare provider.
If your results are outside the normal range, your doctor will discuss them with you and may recommend additional tests or treatments based on your symptoms and medical history.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy