Genetic variant analysis (Single Nucleotide Variant) in plasma or serum using next-generation sequencing
This test examines specific changes (mutations) in your DNA sequence found in blood plasma or serum. These changes may be linked to inherited conditions, cancer risk, or response to treatment.
["Helps identify genetic variations that could influence health risks or treatment options."]
Key facts at a glance
- LOINC
- 83063-8
- Short code
- PTEN gene VCF Ca spec Seq
- Synonyms
- PTEN gene VCF Ca spec Seq
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- sequencing
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for single nucleotide variants (SNVs)—tiny changes in one DNA building block (nucleotide)—that may affect how your body functions. These changes can be inherited or acquired and may relate to conditions like cancer, metabolic disorders, or drug resistance.
Why It Might Be Ordered
Your healthcare provider may recommend this test if you have a family history of certain diseases, are at higher risk for genetic conditions, or if you’re considering genetic counseling or precision medicine approaches.
Sample Collection and Preparation
A blood sample is taken from you, and the plasma or serum portion is used for genetic sequencing. This sample is sent to a lab for detailed DNA analysis.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to avoid certain medications or foods that could interfere with results. Follow your provider’s instructions closely.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
SNVs can influence disease risk, treatment response, or even guide personalized medical decisions. For example, they may help determine if a cancer treatment will work for you or identify inherited conditions that require monitoring.
Short name
NGS SNV Analysis
Frequently asked questions
Will this test show all possible genetic issues?
How long will results take?
Can I ask for a second opinion on these results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy