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Parathyroid Hormone (Active), Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the active form of parathyroid hormone (PTH), a key hormone that helps regulate calcium levels in your body. It’s often checked if you have symptoms of low or high calcium or related conditions.

Quick summary

["Active PTH helps balance calcium and phosphate, influencing bone health and nerve function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63302-4
Short code
PTH Ab Titr Ser IF
Synonyms
PTH Ab Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your doctor may order this test to diagnose or monitor conditions like hypoparathyroidism (low PTH), hyperparathyroidism (high PTH), or kidney disease, which can affect calcium metabolism.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re on blood thinners or have a history of bleeding disorders, let your doctor know.

What the Results Mean

Results help determine if your calcium levels are too high or too low, which can cause symptoms like muscle weakness, bone pain, or abnormal heart rhythms. Your doctor will interpret results in the context of your overall health.

Common Conditions Monitored

This test is used to evaluate conditions such as vitamin D deficiency, kidney disease, or metabolic bone diseases. It’s also checked after surgery involving the parathyroid glands.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Active PTH is crucial because it directly regulates calcium and phosphate levels. While total PTH can be measured, active PTH reflects the biologically active form that actually drives calcium absorption in the gut and bone resorption.

Short name

Active PTH (Serum)

Frequently asked questions

What is the difference between active and total PTH?
Active PTH is the portion of PTH that is biologically functional, while total PTH includes both active and inactive fragments. Active PTH is more precise for diagnosing conditions like pseudohypoparathyroidism.
Can diet or supplements affect this test?
Dietary calcium intake, vitamin D levels, and certain medications (like calcium supplements or anticonvulsants) can influence PTH levels. Your doctor may adjust your diet or medications based on test results.
How often is this test repeated?
Frequency depends on your condition. Some patients need monitoring every few months, while others may only need it once if stable. Follow your doctor’s recommendations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy