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Parathyroid Hormone (Active, Mid-Molecular Weight)

Published: August 9, 2026Updated: August 16, 2026

This test measures the active form of parathyroid hormone (PTH), a key regulator of calcium levels in your body. It helps assess how well your thyroid glands are functioning and whether your calcium balance is being managed properly.

Quick summary

["Active PTH levels help diagnose and monitor conditions affecting calcium metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24347-7
Short code
PTH Mid Mol + Ca Pnl SerPl
Synonyms
PTH Mid Mol + Ca Pnl SerPl
Category
electrolyte
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

PTH plays a critical role in maintaining calcium and phosphorus levels in your blood. When your body needs more calcium, PTH signals bones to release it and kidneys to retain calcium. Low or high PTH levels can indicate underlying health issues, such as hypoparathyroidism or hyperparathyroidism.

When It’s Ordered

Your healthcare provider may recommend this test if you have symptoms like muscle weakness, bone pain, or frequent fractures. It’s also used in patients with kidney disease, vitamin D deficiency, or unexplained calcium imbalances.

Sample Collection and Preparation

A blood sample is taken from a vein, usually in your arm. The sample is processed to separate serum or plasma for testing. This test is typically done after fasting, but your provider will confirm timing with you.

Test Results and Interpretation

Results are compared to standard ranges, though individual results can vary based on age, sex, and health status. Your provider will discuss the meaning of your specific results in the context of your overall health.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

PTH (active, mid-molecule)

Frequently asked questions

What Does It Measure?
This test measures the active, mid-molecular form of PTH, which is the biologically active fragment responsible for regulating calcium levels. It helps identify whether your PTH levels are too high or too low, which can affect bone health and other body functions.
How Might It Be Used?
Results may be used to diagnose conditions like hypoparathyroidism (low PTH), hyperparathyroidism (high PTH), or to monitor treatment for conditions affecting calcium metabolism.
What Are Common Causes of Abnormal Results?
Abnormal results could be due to thyroid disorders, kidney disease, vitamin D deficiency, or certain medications. Always discuss any changes in your results with your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy