Protein Electrophoresis (Serum/Plasma) with Bromocresol Green (BCG) Dye Binding

What This Test Measures

Protein electrophoresis separates blood proteins into different categories (such as albumin, globulins, and other fractions) based on their size and charge. The bromocresol green dye binds to specific proteins, allowing for precise measurement of protein concentrations in each fraction. This helps identify abnormalities in protein distribution that may indicate conditions like liver disease, kidney disease, or certain types of protein disorders.

Why It’s Done

Your healthcare provider may order this test if you have symptoms like unexplained weight loss, swelling, fatigue, or if tests suggest problems with protein metabolism. It can also be used as part of a general health check or to monitor conditions like multiple myeloma, nephrotic syndrome, or chronic liver disease.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum or plasma, which is then analyzed using electrophoresis with bromocresol green dye. No special preparation is needed, but fasting may be advised depending on your specific test order.

Common Conditions Monitored or Diagnosed

This test helps diagnose or monitor conditions such as hypoalbuminemia (low albumin levels), dysproteinemias (abnormal protein patterns), and certain types of cancers or inflammatory diseases. It can also detect conditions affecting protein synthesis or degradation in organs like the liver or kidneys.