Protein Electrophoresis (Serum)
This test measures the different types of proteins in your blood, helping identify abnormalities in protein distribution that may signal conditions like multiple myeloma, liver disease, or kidney problems.
["This test helps diagnose and monitor conditions affecting protein balance in your blood."]
Key facts at a glance
- LOINC
- 5956-8
- Short code
- PT imm NP PPP Cont
- Synonyms
- PT imm NP PPP Cont
- Category
- chemistry
- Sample
- plasma
- Container
- Lavender-top (EDTA) or Green-top (Heparin)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- coag-tissue-factor-induced-factor-substitution-immediately-after-addition-of-normal-plasma
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Protein electrophoresis separates blood proteins into fractions (e.g., albumin, globulins) using an electric field. Each fraction corresponds to distinct protein types, which can be analyzed for concentration and composition. This process helps detect shifts in protein levels that may indicate underlying health issues.
Why It’s Done
Your healthcare provider may order this test to investigate symptoms like unexplained weight loss, fatigue, swelling, or signs of organ dysfunction. It’s also used to monitor chronic conditions like kidney disease or autoimmune disorders.
Sample Preparation
A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum (the liquid part after clotting) for testing. No special preparation is needed, but fasting may be advised depending on your specific test order.
Common Conditions Monitored
This test can reveal issues such as abnormal protein patterns in diseases like multiple myeloma (cancer of plasma cells), liver cirrhosis, or nephrotic syndrome (kidney disease causing protein loss). It may also help assess immune system disorders or nutritional deficiencies.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Protein electrophoresis is a key diagnostic tool for identifying protein abnormalities that can’t be detected by standard blood tests alone. It provides detailed insights into protein distribution, aiding in early diagnosis and treatment planning for serious conditions.
Short name
Serum Protein Electrophoresis
Frequently asked questions
What does a protein electrophoresis test show?
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy