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: Protein Electrophoresis Panel, Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

: A protein electrophoresis test separates the proteins in your blood into groups so your care team can look for abnormal patterns, such as a missing or extra protein band.

Quick summary

[": This test gives a broad picture of the major protein groups in your blood rather than measuring a single substance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
52120-3
Short code
PT NP 1h separate PPP
Synonyms
PT NP 1h separate PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
coag-tissue-factor-induced-factor-substitution-addition-of-normal-plasma-h-post-incubation-separate-tubes
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What This Test Measures

: Your blood contains many different proteins, including albumin and a variety of globulins. Protein electrophoresis uses an electrical field to spread these proteins out so they can be sorted by their size and charge into recognizable bands.

: Why Your Clinician May Order It

: This test is often used to investigate unusual protein levels, unexplained fatigue, recurring infections, or symptoms that could relate to abnormal protein production. It can also help monitor a known protein abnormality over time.

: How the Sample Is Collected

: A small blood sample is drawn from a vein, usually in your arm, and the serum or plasma is separated for testing. No special preparation is typically required unless your clinician gives other instructions.

: What the Results Mean

: Your report describes the pattern and relative amounts of protein bands rather than a single number. Your clinician interprets the pattern together with your symptoms, other lab results, and medical history, and may order follow-up tests if something looks unusual.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: plasma

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: SPEP

Frequently asked questions

: Does this test diagnose a specific disease by itself?
: No. It shows a protein pattern that your clinician interprets alongside other information and tests.
: Do I need to fast before this test?
: Fasting is usually not required, but follow any instructions your clinician or lab provides.
: Will I get a single numeric result?
: Results are typically reported as a pattern of protein bands and their relative proportions, not one simple number.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy