Prostate-Specific Antigen (PSA) with Free PSA Ratio and Total PSA/Creatinine Ratio (24-hour urine)
This test measures prostate-specific antigen (PSA) levels in your urine over 24 hours, along with ratios to help assess prostate health and potential concerns like benign prostatic hyperplasia (BPH) or prostate cancer.
["This test provides key insights into prostate function and risk factors that may require further evaluation."]
Key facts at a glance
- LOINC
- 106302-3
- Short code
- PT Prostate W RNC IV
- Synonyms
- PT Prostate W RNC IV
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- pt
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like frequent urination, difficulty urinating, or if you’re at higher risk for prostate issues. It can also be part of routine screening for men over a certain age or those with a family history of prostate cancer.
What to Expect Before the Test
No special preparation is needed. You’ll collect your urine over a full 24-hour period in a container provided by your lab. Drink plenty of fluids to ensure adequate urine volume, but avoid alcohol or certain medications that might affect PSA levels.
What the Test Measures
The test measures PSA in your urine, including free PSA (the unbound form) and total PSA (both free and bound). It also calculates ratios between these forms and compares PSA to creatinine levels in urine to assess prostate health and function.
Possible Results and Next Steps
Results are used to evaluate prostate health, detect abnormalities, or monitor conditions like BPH or prostate cancer. Elevated PSA levels may prompt further diagnostic testing, such as a digital rectal exam or additional imaging.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated PSA levels in urine can indicate prostate inflammation, infection, benign enlargement, or cancer. The free PSA ratio helps distinguish between benign and malignant causes, while the PSA-to-creatinine ratio can assess kidney function and prostate-specific secretion. This test is particularly useful for monitoring prostate health in men with known risk factors or symptoms.
Short name
PSA Profile (Urinary)
Frequently asked questions
What does a normal PSA level in urine mean?
Can diet or medications affect PSA levels in urine?
Is this test the same as a blood PSA test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy