Total Protein with Albumin-to-Globulin Ratio (Serum/Plasma)
This test measures total protein in your blood and evaluates the balance between albumin and globulin proteins, which can help assess overall protein status and immune function.
["Understanding your protein balance and total protein levels can aid in diagnosing and managing conditions like malnutrition, infections, or liver/kidney disease."]
Key facts at a glance
- LOINC
- 58741-0
- Short code
- PT Skull to thigh W RNC IV
- Synonyms
- PT Skull to thigh W RNC IV
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- pt
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does Total Protein Measure?
Total protein includes all proteins in your blood, primarily albumin and globulin. Albumin helps maintain fluid balance in your tissues, while globulins support immune function and transport certain substances.
Why Is the Albumin-to-Globulin Ratio Important?
This ratio compares albumin (the smaller, more abundant protein) to globulins (which include antibodies and other immune proteins). A higher ratio may suggest liver disease or malnutrition, while a lower ratio could indicate chronic infections or inflammation.
Common Uses in Healthcare
This test is often used to screen for conditions affecting protein synthesis (e.g., liver disease), immune function, or nutritional status. It may also be part of routine monitoring for chronic illnesses.
How Is This Test Performed?
A blood sample is drawn, typically from your arm, and sent to a lab. The lab measures total protein content and separates albumin and globulin fractions using specialized techniques like electrophoresis or nephelometry.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated total protein or albumin may indicate dehydration, chronic inflammation, or certain cancers. Low total protein or a high globulin-to-albumin ratio can signal liver disease, malnutrition, or immune disorders. Always discuss results with your healthcare provider for personalized interpretation.
Short name
Protein Profile & Ratio Test
Frequently asked questions
What causes abnormal total protein levels?
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy