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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the combined amount of all proteins found in your blood serum, which helps assess overall protein status and potential conditions like malnutrition or kidney disease.

Quick summary

["Your blood protein levels can signal health risks or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18398-8
Short code
PV2 Ab Titr CSF CF
Synonyms
PV2 Ab Titr CSF CF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order this test to evaluate protein levels in conditions such as kidney disease, liver problems, malnutrition, or chronic inflammation. It can also help monitor treatment responses in certain diseases.

What Does It Measure?

Total protein includes albumin and globulins, which perform vital functions like maintaining blood pressure, transporting nutrients, and supporting immune function. Abnormal levels may indicate underlying health concerns.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum (the liquid part after clotting) for testing. This test does not require fasting.

What to Expect Before the Test

No special preparation is needed, but inform your healthcare provider about any medications or supplements you take, as they may affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes abnormal protein levels?
Abnormal protein levels can result from conditions like kidney disease (which may cause protein to leak into urine), liver disease, malnutrition, or chronic inflammation. Medications, pregnancy, or certain infections may also influence results.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing schedule. Follow-up with your healthcare provider to discuss any findings.
Can diet affect this test?
Dietary changes may not directly impact total protein levels, but a balanced diet rich in protein can support overall health. Avoiding excessive alcohol or certain medications (like diuretics) can help ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy