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Total Protein in Body Fluid (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood or other body fluids, which helps assess overall protein levels and potential issues like dehydration, liver disease, or kidney problems.

Quick summary

["Your doctor may check protein levels to diagnose or monitor conditions affecting protein balance in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31065-6
Short code
PV3 Ab Titr Fld CF
Synonyms
PV3 Ab Titr Fld CF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
CPT
86430
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors order this test to evaluate conditions such as malnutrition, kidney disease, liver disease, or fluid imbalances. It can also help determine if you’re retaining too much fluid or if your body isn’t absorbing nutrients properly.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it involves a blood draw. If it’s a urine or other fluid sample, follow any specific instructions your doctor provides.

What Happens During the Test?

For blood tests, a healthcare provider will draw a small amount of blood from your arm. For urine or other fluid samples, you may need to collect a sample at home or provide it during a visit. The sample is then sent to a lab for analysis.

What Do Results Mean?

Results help identify whether your protein levels are too high or too low. High levels might suggest conditions like dehydration or multiple myeloma, while low levels could indicate malnutrition, liver or kidney disease, or severe infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal protein levels can signal underlying health issues. For example, low protein may indicate poor nutrient absorption or organ dysfunction, while elevated levels could point to conditions like dehydration, inflammation, or certain cancers. Your doctor will interpret results in the context of your overall health and symptoms.

Short name

Total Protein

Frequently asked questions

What causes low protein levels?
Low protein levels can result from conditions like liver disease, kidney disease, malnutrition, severe infections, or certain medications. Chronic conditions, rapid weight loss, or excessive vomiting/diarrhea may also contribute.
What causes high protein levels?
High protein levels can occur with dehydration, multiple myeloma (a blood cancer), severe burns, or certain kidney diseases. Inflammation or exposure to certain toxins may also raise protein levels temporarily.
Do I need to avoid certain foods before this test?
No specific diet restrictions apply unless your doctor specifies a fasting requirement for blood tests. If you’re unsure, ask your lab or doctor about any special instructions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy