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Prostate-Specific Antigen (PSA) Concentration, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of prostate-specific antigen (PSA) in your blood. PSA is a protein produced by both healthy and diseased prostate cells, often used to monitor or screen for prostate health issues.

Quick summary

["PSA levels can help assess prostate health, including potential risks for prostate cancer or other prostate-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9904-4
Short code
P wave dur L-I
Synonyms
P wave dur L-I
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a PSA test to check for signs of prostate cancer, evaluate symptoms of an enlarged prostate (benign prostatic hyperplasia), or monitor existing prostate conditions. It can also be used in screening for men at higher risk.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to avoid ejaculation for 2–7 days before testing if it’s part of a screening or monitoring plan. Drink plenty of water the day of your visit to help your blood flow smoothly.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm. The sample is then sent to a lab for analysis. The test typically takes a few minutes, and you may feel slight discomfort but no lasting effects.

What the Results Mean

PSA levels vary by age, overall health, and medical history. Higher-than-normal levels may signal prostate issues, but they can also be influenced by factors like age, recent ejaculation, or prostate inflammation. Your results will be discussed with your doctor in the context of your full medical picture.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PSA Blood Test

Frequently asked questions

What causes PSA levels to change?
PSA levels can fluctuate due to factors like age, recent ejaculation, prostate inflammation, urinary tract infections, or certain medications. Prostate surgery, biopsies, or other procedures can also temporarily affect PSA levels.
How often should I get a PSA test?
The frequency depends on your age, medical history, and risk factors. The U.S. Preventive Services Task Force recommends against routine PSA screening for men under 55, but your doctor may suggest it if you have a family history of prostate cancer or other risk factors.
Can PSA levels be affected by diet or supplements?
Some foods and supplements, like cruciferous vegetables or zinc, may influence prostate health, but they don’t directly alter PSA levels. Always discuss any supplements with your doctor before use.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy