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Pyruvate and Creatinine, 24-Hour Urine

Published: August 9, 2026Updated: August 16, 2026

Measures pyruvate and creatinine in urine collected for 24 hours. Creatinine helps account for urine concentration and assess collection completeness.

Quick summary

["This test measures 24-hour urinary pyruvate and creatinine to help evaluate metabolism and the adequacy of the urine collection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25130-6
Short code
PYD/Creat 24h Ur-sRto
Synonyms
PYD/Creat 24h Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of pyruvate, a substance involved in energy metabolism, and creatinine in urine collected over 24 hours. Creatinine is also used to help account for variations in urine concentration.

Why might I need this test?

A clinician may order this test as part of an evaluation of suspected metabolic or mitochondrial disorders. The results may also help determine how much of the measured substance is being excreted and whether the urine collection was adequate.

How is the test performed?

You usually collect all urine into a labeled container for exactly 24 hours. The start and end times are recorded, and the container is then sent to the laboratory for analysis.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. Avoid fasting, major changes in diet, or unusual exercise unless your clinician specifically recommends them, because these can affect the results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An elevated or reduced amount of urinary pyruvate may occur with changes in energy metabolism, illness, diet, or exercise and does not by itself establish a specific disorder. Urinary creatinine can vary with muscle mass, hydration, and collection completeness, so both results should be interpreted together and in the context of the clinical evaluation.

Short name

24-Hour Urine Pyruvate/Creatinine

Frequently asked questions

Why is creatinine included in this test?
Creatinine helps account for how concentrated the urine is and may help assess whether the 24-hour collection appears adequate. It is commonly used to interpret urinary measurements.
How do I collect a 24-hour urine sample?
Empty your bladder at the recorded starting time, then collect all urine for the next 24 hours in the provided container. If you miss a collection or the timing is uncertain, ask the laboratory how to proceed.
Does an abnormal result confirm a metabolic disorder?
No. Urinary pyruvate and creatinine can be affected by several nonmedical factors, so abnormal results require clinical context and sometimes repeat or additional testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy