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Pyruvate concentration in serum/plasma (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of pyruvate, a metabolic intermediate, in your blood. Pyruvate is produced during cellular respiration and serves as a precursor to other important compounds like lactate and glucose.

Quick summary

["Understanding your pyruvate levels can help assess how well your body’s energy production processes are functioning."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27957-0
Short code
Pyruvate 4h p chal Bld-mCnc
Synonyms
Pyruvate 4h p chal Bld-mCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to metabolic disorders, such as lactic acidosis, mitochondrial diseases, or unexplained fatigue. It may also be part of a broader evaluation for inherited metabolic disorders or to monitor certain treatments.

What to Expect Before the Test

No special preparation is typically required, but you may be asked to fast for a few hours before the blood draw. Wear comfortable clothing and arrange for someone to drive you home if you’re taking sedatives or other medications that cause drowsiness.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm. The sample is then sent to a lab for analysis using a specialized method to measure pyruvate concentration.

What the Results Mean

Results are interpreted by your healthcare provider based on your clinical picture. Elevated levels may suggest metabolic imbalances, while lower levels could indicate certain enzyme deficiencies or other metabolic issues. Your provider will discuss findings in the context of your health history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum/plasma pyruvate level

Frequently asked questions

What are the normal reference ranges for this test?
Reference ranges can vary by lab and individual factors like age, sex, and overall health. Your provider will use your specific results alongside your medical history and symptoms to determine if levels are within a typical range or if further investigation is needed.
Can high or low pyruvate levels cause health problems?
Yes, abnormal pyruvate levels can be associated with serious conditions. For example, high levels may indicate lactic acidosis, a dangerous buildup of lactic acid in the blood, which can harm organs. Low levels might suggest mitochondrial disorders or deficiencies in enzymes involved in pyruvate metabolism.
Does this test require fasting?
Sometimes, but not always. Your provider will specify if fasting is needed before the test. If fasting is required, follow their instructions carefully to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy