Pyruvate and Creatinine, 24-Hour Urine
Measures pyruvate and creatinine in urine collected for 24 hours. Creatinine helps account for urine concentration, and the results may be interpreted individually or as a ratio.
["This test measures urine pyruvate and creatinine to help evaluate possible metabolic or mitochondrial disorders."]
Key facts at a glance
- LOINC
- 44400-0
- Short code
- Pyruvate/Creat 24h Ur
- Synonyms
- Pyruvate/Creat 24h Ur
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures the amount of pyruvate, a substance involved in energy metabolism, and creatinine, a waste product commonly used to assess urine concentration, in urine collected over 24 hours.
Why might I need this test?
It may be used to help evaluate unexplained symptoms or suspected problems in cellular energy metabolism, including mitochondrial disorders or conditions affecting pyruvate metabolism. Results are interpreted with symptoms, medical history, and other laboratory tests.
How is the test performed?
You collect all urine for exactly 24 hours in the container provided by the laboratory. The laboratory then measures pyruvate and creatinine and may calculate their ratio to reduce the effect of variations in urine concentration.
How do I prepare for the test?
Follow the laboratory's collection instructions, including the start and end times and where to store the container. Tell your clinician about medicines, supplements, illness, or changes in urine output that could affect the results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
An elevated amount or ratio of urine pyruvate may be seen with inherited mitochondrial or metabolic disorders, particularly disorders affecting pyruvate metabolism or the pyruvate dehydrogenase pathway. Abnormal results can also reflect collection problems, hydration differences, diet, medicines, or other factors, so they should not be used alone to establish a diagnosis.
Short name
24-hour urine pyruvate and creatinine
Frequently asked questions
Does the test require a timed urine collection?
Why is creatinine measured with pyruvate?
Can one abnormal result diagnose a metabolic disorder?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy