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Urine Pyruvate-to-Creatinine Ratio

Published: August 9, 2026Updated: August 16, 2026

Measures urine pyruvate relative to urine creatinine, helping account for differences in urine concentration when evaluating metabolic conditions.

Quick summary

["This urine test compares pyruvate with creatinine to help evaluate possible abnormalities in energy metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13805-7
Short code
Pyruvate/Creat Ur
Synonyms
Pyruvate/Creat Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of pyruvate in urine relative to the amount of creatinine. Creatinine is used as a reference marker because its level in urine varies with urine concentration.

Why might I need this test?

A clinician may order this test when investigating unexplained symptoms or laboratory findings that could be related to impaired energy metabolism, mitochondrial disorders, or an imbalance in acid production.

How is the test performed?

A urine sample is tested to determine its pyruvate and creatinine concentrations. The laboratory then calculates the pyruvate-to-creatinine ratio. The result is interpreted alongside your symptoms, other laboratory tests, and medical history.

How do I prepare for the test?

Follow the collection instructions provided by your clinician, including whether a first-morning or timed urine sample is required. Record the collection time and provide the full sample with any required paperwork.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Pyruvate/Creatinine Ratio

Frequently asked questions

What does pyruvate mean?
Pyruvate is a substance formed during the breakdown of carbohydrates and other energy sources. Cells convert it into energy through a process that requires oxygen.
Why is creatinine included in the result?
Urine concentration can change throughout the day. Comparing pyruvate with creatinine helps account for those changes and provides a more useful measure of urinary pyruvate.
Does an abnormal result mean I have a mitochondrial disorder?
No. An elevated ratio can have several causes and must be interpreted with other laboratory results, symptoms, and your clinical history. Your healthcare professional can explain the findings in your context.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy