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Total Protein (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess overall protein balance and potential liver or kidney issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9946-5
Short code
Q wave dur L-V4
Synonyms
Q wave dur L-V4
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Total Protein?

Total protein is a measure of all protein substances in your blood, excluding red blood cells and other cells. It reflects the balance between protein production and loss in your body. Proteins are essential for many bodily functions, including maintaining fluid balance, supporting immune function, and transporting nutrients and waste products.

Why Might You Need This Test?

Doctors may order a total protein test to diagnose or monitor conditions affecting protein levels, such as liver disease, kidney disease, malnutrition, or certain immune disorders. It can also help evaluate the effectiveness of treatments for these conditions.

What to Expect Before the Test

No special preparation is usually needed for this test. You may have a blood sample drawn from a vein in your arm. If you’re on a blood thinner, let your healthcare provider know before the test.

What Are Possible Results?

Results are typically reported as a total protein concentration in grams per deciliter (g/dL). While reference ranges can vary slightly by lab, lower than expected levels may suggest malnutrition or liver/kidney problems, while higher levels could indicate conditions like dehydration, multiple myeloma, or severe infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How long does it take to get my total protein test results?
Results are usually available within 1 to 3 business days, depending on your lab and healthcare provider’s workflow. Follow-up with your doctor to discuss any abnormal results.
Can diet affect my total protein test results?
Yes, diet can influence protein levels. High-protein diets or certain medical conditions may temporarily alter results. Avoid extreme dietary changes before testing to ensure accurate results.
What if my total protein is low or high?
If your results are outside the expected range, your doctor may recommend further tests or treatments. Low protein could signal malnutrition or organ dysfunction, while high protein might indicate dehydration or other underlying health issues. Always discuss findings with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy