Red Blood Cell Count with Manual Differential (Manual CBC with Differential)

What Does This Test Measure?

Your red blood cell (RBC) count, which includes the total number of RBCs in your blood. This test also evaluates the proportions of different types of white blood cells (neutrophils, lymphocytes, monocytes, eosinophils, and basophils) using a manual microscope count. The manual method allows for more precise identification of cell types compared to automated machines.

Why Might You Need This Test?

Doctors may order this test to diagnose or monitor conditions such as anemia, infections, blood disorders (like leukemia), or immune system issues. It’s also useful for evaluating responses to treatments or detecting subtle changes in blood cell composition.

How Is This Test Performed?

A small sample of your blood is drawn from a vein, typically in your arm. The blood is then examined under a microscope by a trained lab technician who counts and categorizes each cell type manually. This process is slower than automated tests but offers greater detail.

What Are Common Uses?

This test is often used when a more detailed blood picture is needed, such as in cases where automated CBC results seem abnormal but aren’t clearly explained. It’s also used in research, specialized clinical settings, or when patients have complex blood disorders.