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Red Blood Cell Membrane Function Evaluation (Peripheral Blood)

Published: August 9, 2026Updated: August 17, 2026

This test assesses how well your red blood cells maintain their structure and function, which is important for healthy circulation and oxygen transport.

Quick summary

["Understanding your RBC membrane health can help identify issues that may affect your blood’s ability to carry oxygen efficiently."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
98905-3
Short code
RBC membrane eval Pnl RBC
Synonyms
RBC membrane eval Pnl RBC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
44
Ref high
147
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, pale skin, shortness of breath, or if they suspect conditions such as hereditary spherocytosis, elliptocytosis, or other red blood cell disorders. It may also be part of a broader evaluation for anemia or blood disorders.

What to Expect Before the Test

You’ll typically have a simple blood draw from a vein in your arm. No special preparation is usually needed, but inform your provider about any medications or recent illnesses.

What the Test Measures

This test evaluates multiple aspects of red blood cell membrane integrity and function, including stability, shape, and resistance to stress. Specific measurements may include osmotic fragility, membrane protein levels, or other functional indicators.

Common Conditions Monitored

This test helps diagnose or monitor conditions like hereditary red blood cell disorders, autoimmune hemolytic anemia, or other conditions that affect RBC structure and survival.

Reference range

Adult: 44-147 U/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

RBC Membrane Function Test

Frequently asked questions

What does my test result mean?
Results may indicate whether your RBC membranes are functioning normally or if there are signs of damage or dysfunction. Abnormal results could point to underlying health issues that need further evaluation or treatment.
How long will I need to wait for results?
Results are usually available within a few days to a couple of weeks, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can I do anything to prepare for this test?
No special preparation is required, but avoid taking blood-thinning medications (like aspirin) unless cleared by your provider, as they may affect blood test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy