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Red Blood Cell Morphology Profile (Peripheral Blood)

Published: August 9, 2026Updated: August 17, 2026

This test examines the size, shape, and appearance of your red blood cells (RBCs) under a microscope. It helps identify abnormalities that may signal conditions like anemia, infections, or blood disorders.

Quick summary

["Assessing your RBCs can reveal hidden health issues that might not cause obvious symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
58408-6
Short code
RBC morphology pnl Bld
Synonyms
RBC morphology pnl Bld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Doctors may order this test if you have symptoms like fatigue, pale skin, unusual bruising, or unexplained bleeding. It’s also used to diagnose or monitor conditions like anemia, blood disorders (e.g., sickle cell disease), or infections.

What to Expect

No special preparation is needed, but inform your doctor about any medications or conditions that might affect results.

Common Findings

Normal RBCs are usually round and uniform in size. Abnormal shapes (e.g., spherocytes, elliptocytes, or poikilocytes) may indicate underlying health concerns. Size variations (e.g., microcytes or macrocytes) can also signal different conditions.

Possible Conditions Linked to RBC Morphology

Changes in RBC shape or size can signal conditions like hereditary spherocytosis, thalassemia, iron deficiency anemia, or certain infections. It may also help detect early signs of autoimmune disorders or bone marrow problems.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Red Blood Cell Shape Check

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time.
Can I eat or drink before this test?
No special diet is required, but avoid heavy meals or caffeine before your blood draw to minimize discomfort.
Will I feel pain during the blood draw?
Most people experience mild discomfort, but it usually fades quickly. A numbing cream may be applied beforehand to reduce pain.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy