Cerebrospinal Fluid Red Blood Cell Count (Manual Microscopic Count)
This test measures the number of red blood cells in your cerebrospinal fluid (CSF), which is the fluid surrounding your brain and spinal cord. It helps identify conditions affecting the blood-brain barrier or blood flow into the CSF.
["This test helps diagnose bleeding, inflammation, or other issues in your central nervous system."]
Key facts at a glance
- LOINC
- 46092-3
- Short code
- RBC tube4 # CSF Manual
- Synonyms
- RBC tube4 # CSF Manual
- Category
- chemistry
- Sample
- csf
- Container
- Sterile tube
- Units
- N/A
- Ref low
- 4.2
- Ref high
- 5.9
- Critical range
- 2 N/A – 7 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- manual-count
- CPT
- 85041
- SNOMED
- 900000000000003001
- Specimen volume
- 1-2 mL
- Stability
- Immediate analysis required, Refrigerated: 1h
- Hemolysis max
- 200
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, vision changes, or neurological issues that could suggest bleeding, infection, or inflammation in the brain or spinal cord. It’s often part of a broader evaluation for conditions like meningitis, subarachnoid hemorrhage, or traumatic brain injury.
How the Test Works
A small sample of your CSF is collected through a procedure called a lumbar puncture (spinal tap). The sample is then examined under a microscope by a trained technician to count the red blood cells. Unlike automated blood counts, this method provides a detailed, manual count for accuracy.
What to Expect Before the Test
You’ll typically lie on your side with your knees bent to your chest. The procedure involves inserting a needle into your lower back to collect the CSF. You may feel pressure or a slight sting, but it’s usually not painful. You’ll be asked to lie still for a few minutes afterward to prevent bleeding.
What to Expect During the Test
The test itself is quick, usually taking less than 15 minutes. You’ll be monitored closely to ensure no complications occur. Afterward, you may feel mild soreness or a temporary headache, which can be managed with over-the-counter pain relievers.
Reference range
Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated red blood cell counts in CSF can indicate bleeding into the spinal fluid, such as from a traumatic injury, aneurysm, or vascular malformation. Persistent or high levels may also suggest chronic conditions like subarachnoid hemorrhage or certain inflammatory diseases. Low counts are less commonly significant but could indicate technical issues during the procedure or rare blood-brain barrier dysfunction.
Short name
CSF RBC Count
Frequently asked questions
How long does it take to get results from this test?
Can I eat or drink before this test?
Is this test painful?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy