24-Hour Urinary Panel for Protein and Creatinine (Protein-to-Creatinine Ratio)

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or unexplained weight changes, or if they suspect kidney disease, diabetes, or other conditions affecting protein excretion. It’s also used to monitor chronic kidney disease or track responses to treatments.

What to Expect Before the Test

You’ll collect all urine for 24 hours (typically from one morning to the next morning). Drink plenty of water but avoid foods high in salt or protein if instructed. Store urine in a cool place and return it to the lab on time.

How the Test Works

The lab analyzes urine samples for protein levels and creatinine (a waste product from muscle metabolism). The ratio helps determine if your kidneys are filtering protein properly, which can indicate kidney damage or disease.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like diabetic nephropathy, glomerulonephritis, or nephrotic syndrome. It can also help track protein loss in conditions like multiple myeloma or certain autoimmune diseases.