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Reagin Antibody (Serum) - Atypical Antibody Screening

Published: August 9, 2026Updated: August 16, 2026

This test measures certain antibodies that may indicate an allergic reaction or atypical immune response, often used to screen for conditions like atypical pneumonia or certain parasitic infections.

Quick summary

["This screening helps identify potential allergic or immune-related reactions that may require further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22462-6
Short code
Reagin Ab Ser-aCnc
Synonyms
Reagin Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Reagin antibodies are a type of antibody that can appear in response to certain infections or allergic reactions. This test detects their presence in your serum to help identify possible underlying causes for symptoms like fever, cough, or fatigue.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms suggestive of atypical pneumonia (e.g., prolonged cough, fever without typical bacterial causes) or if you’ve been exposed to potential allergens or parasites.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum, which is then tested for reagin antibodies using an immunoassay method.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications, recent infections, or allergies that could affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Reagin antibodies are not specific to any single disease but can signal an immune response to certain pathogens or allergens. Positive results may prompt further diagnostic testing, such as specific antibody testing or imaging, to determine the exact cause of your symptoms.

Short name

Reagin Antibody Screen

Frequently asked questions

When might I get my results back?
Results are typically available within 1–3 business days. Your provider will discuss them in detail during your follow-up visit.
What does a positive result mean?
A positive result suggests the presence of reagin antibodies, which may indicate an allergic or immune response. Further testing is needed to identify the specific cause.
Can I take anything to lower my antibody levels before the test?
No, there are no known steps to reduce antibody levels before this screening test. Focus on resting and staying hydrated if you have symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy