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Serum or plasma concentration of creatinine (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures how well your kidneys are filtering waste products from your blood. Creatinine is a natural waste product that builds up when muscles break down proteins.

Quick summary

["Kidney function depends on this test to check how well waste is removed from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
8618-1
Short code
Recording dur EKG
Synonyms
Recording dur EKG
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine levels help doctors assess kidney function by measuring how efficiently your kidneys filter waste products like creatinine from your blood. Healthy kidneys remove creatinine and other waste products through urine. If levels are too high, it may indicate kidney problems or reduced kidney function.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood draw or urine sample collected, depending on the type of creatinine test being done. If it’s a blood test, you’ll likely sit or lie down while a healthcare provider inserts a small needle into a vein in your arm.

What the Results Mean

Results are compared to a reference range that varies by lab and age. High levels may signal kidney issues, while low levels could suggest dehydration or muscle breakdown. Your doctor will interpret results in relation to your overall health and symptoms.

Common Causes of Abnormal Results

High creatinine levels can be caused by kidney disease, dehydration, or conditions that increase muscle breakdown (e.g., severe illness or injury). Low levels may occur with dehydration, overhydration, or muscle loss. Other factors like diet, medications, or certain medical conditions can also affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Creatinine Level

Frequently asked questions

What does a high creatinine level mean?
A high creatinine level often signals that your kidneys aren’t working as well as they should, which can be an early sign of kidney disease or damage. Your doctor may recommend further testing or adjustments to your treatment plan if levels are elevated.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and overall condition. Some people with chronic conditions like diabetes or heart disease may need it more frequently, while others may only need it occasionally.
Can diet affect creatinine levels?
Yes, diet can influence creatinine levels. Eating a high-protein diet may temporarily increase creatinine levels, as protein breakdown produces creatinine. However, your doctor will consider your overall diet and health when interpreting results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy