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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to check for low-grade inflammation or risk of heart disease.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7595-2
Short code
Red Pepper BasoBnd Ab Qn
Synonyms
Red Pepper BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lhr
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

High-sensitivity CRP (hs-CRP) is primarily used to assess the risk of cardiovascular events, such as heart attacks or strokes, especially in people without obvious symptoms of inflammation. It can also help monitor chronic conditions like arthritis or other inflammatory diseases by detecting low-level inflammation that might not be detected by other tests alone.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed using a specialized immunoassay method to measure very small amounts of CRP. No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.

What Does a High or Low Result Mean?

Results are interpreted based on your overall health, symptoms, and other test results. A higher hs-CRP level may indicate increased inflammation or cardiovascular risk, while a lower level suggests reduced risk. Your doctor will discuss these results in the context of your medical history and other findings.

Common Causes of Abnormal Results

Elevated hs-CRP can be caused by infections, injuries, autoimmune diseases, or other inflammatory conditions. It may also rise after surgery or during stress. Low levels are less commonly significant unless part of a broader evaluation for chronic inflammation or cardiovascular health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Why It Matters

Short name

hs-CRP

Frequently asked questions

Why might my doctor order this test?
Your doctor may order hs-CRP to evaluate your risk of heart disease, monitor chronic conditions like arthritis or lupus, or check for signs of inflammation in your body. It can also help guide decisions about medications or lifestyle changes.
What should I do if my hs-CRP is elevated?
If your hs-CRP is elevated, your doctor may recommend lifestyle changes (like diet, exercise, or stress management), medications, or further testing to identify the cause of inflammation. Follow their advice closely and discuss any concerns.
Can I avoid this test if I don’t have symptoms?
While hs-CRP isn’t always needed if you feel healthy, some doctors recommend it as a preventive measure for people at higher risk of heart disease, especially those with risk factors like high blood pressure, diabetes, or a family history of heart problems. Always ask your doctor if this test is right for you.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy