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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes important substances like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can indicate overall health, hydration status, or potential conditions like liver disease or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43941-4
Short code
Red top grass IgE/IgE total %
Synonyms
Red top grass IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Blood proteins play a critical role in many bodily functions. High or low levels can signal underlying health issues, such as dehydration, liver disease, or kidney problems. Your doctor may order this test to check for these conditions or monitor existing ones.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood, which usually takes just a few minutes. If you’re on blood thinners or have a history of bleeding issues, let your doctor know.

What the Results Mean

Results are typically reported as a total protein value (in grams per deciliter, or g/dL). While reference ranges vary slightly by lab, values outside the normal range may prompt further investigation, such as additional blood tests or a visit to your doctor.

Common Conditions Affecting Results

High protein levels might occur with dehydration, certain infections, or conditions like multiple myeloma. Low protein levels can result from liver disease, kidney problems, malnutrition, or severe burns. Your doctor will discuss these findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What questions might I have about this test?
This test is often used to assess overall protein status in the blood. If you have symptoms like swelling, fatigue, or unexplained weight loss, your doctor may recommend it. It’s also part of routine checks for chronic conditions like kidney or liver disease.
How long will I need to wait for my results?
Results are usually available within a few days to a week, depending on your lab and healthcare provider. Your doctor will contact you once they’re ready to discuss them.
Can I eat or drink before this test?
No special diet is required, but avoid heavy meals or alcohol before your blood draw. Drink water as usual unless instructed otherwise by your doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy