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Angiotensinogen (Serum) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of angiotensinogen, a protein in your blood that helps regulate blood pressure and fluid balance.

Quick summary

["Angiotensinogen levels can help assess kidney function and blood pressure regulation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56757-8
Short code
Renin 100M p chal Plas-cCnc
Synonyms
Renin 100M p chal Plas-cCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions related to kidney disease, high blood pressure, or fluid imbalances. It could also be part of a broader evaluation for hereditary angioedema or other genetic blood pressure-related disorders.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear a loose-fitting shirt for easy access to your arm.

How the Test Is Performed

A healthcare professional will insert a needle into a vein in your arm to collect a blood sample. You may feel a brief pinch, but the procedure is quick and typically painless. The blood will be sent to a lab for analysis.

What the Results Mean

Results are compared to a reference range specific to your age, sex, and overall health. Low levels may indicate kidney problems or genetic conditions affecting fluid balance, while high levels could suggest liver disease or other metabolic issues.

Reference range

Adult: 44-147 U/LN/A

Specimen: plasma

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal angiotensinogen levels can signal underlying conditions like hereditary angioedema, chronic kidney disease, or liver dysfunction. It may also help diagnose or monitor conditions affecting blood pressure regulation, fluid retention, or vascular health. Always discuss results with your provider for personalized interpretation.

Short name

Angiotensinogen

Frequently asked questions

What causes angiotensinogen levels to be low?
Low angiotensinogen levels can result from genetic disorders (such as hereditary angioedema), chronic kidney disease, or liver disease. Rarely, it may also be linked to certain medications or metabolic conditions. If you suspect an underlying cause, talk to your doctor about further testing or lifestyle adjustments.
How often should I get this test?
The frequency depends on your health status. If you have a known condition like hereditary angioedema, your provider may recommend regular monitoring. Otherwise, this test is often part of a one-time evaluation for symptoms or specific clinical concerns.
Can diet or medications affect angiotensinogen levels?
Dietary changes alone typically do not significantly alter angiotensinogen levels, but certain medications (such as angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers) may influence its production. Always inform your doctor about all medications you take before the test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy