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Plasma Renin Activity (measured via a specific chromogenic assay)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity level of renin, an enzyme produced by your kidneys that plays a key role in regulating blood pressure and fluid balance.

Quick summary

["Renin activity helps assess kidney function and blood pressure regulation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58898-8
Short code
Renin 4h p chal Plas-cCnc
Synonyms
Renin 4h p chal Plas-cCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
44
Ref high
147
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84075
SNOMED
27550007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Renin Activity Testing For?

Renin activity testing helps evaluate how well your kidneys are producing this enzyme. It can be used to diagnose or monitor conditions affecting blood pressure, kidney function, or hormonal imbalances, such as primary or secondary hypertension, aldosteroneism, or adrenal disorders.

How Is This Test Performed?

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate plasma, which is then analyzed in a lab using a specialized chromogenic assay to measure renin activity levels.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like high blood pressure, unexplained fluid retention, or if they suspect conditions like renin-secreting tumors, kidney disease, or hormonal imbalances affecting blood pressure regulation.

What Does the Test Result Mean?

Results are not provided with specific numeric ranges, as they depend on clinical context. Elevated or low levels may indicate specific underlying conditions that require further evaluation by your doctor.

Reference range

Adult: 44-147 U/LN/A

Specimen: plasma

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Renin Activity Testing

Short name

Renin Activity

Frequently asked questions

Why was this test ordered for me?
Your doctor may have ordered this test to investigate potential kidney-related issues, hormonal imbalances, or conditions affecting blood pressure regulation. It helps determine whether your kidneys are producing renin at a level consistent with normal function or if there is an abnormality that needs further medical attention.
What are the typical reference ranges for renin activity?
Reference ranges for renin activity can vary depending on the clinical context, such as whether you are diagnosed with hypertension or another condition. Your results will be interpreted in relation to your specific health situation, and your doctor will provide a detailed explanation.
How long does it take to get the results of this test?
Results from this test are typically available within a few days to a week, depending on the lab’s processing schedule. Your healthcare provider will contact you once the results are ready, usually through your regular doctor’s office or lab results portal.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy