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Plasma Renin Activity (measured as renin concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the activity of renin, an enzyme produced by your kidneys that helps regulate blood pressure and fluid balance.

Quick summary

["Renin activity helps assess kidney function and blood pressure regulation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
1622-0
Short code
Renin 5h p 600 ug Fur PO Plas-cCnc
Synonyms
Renin 5h p 600 ug Fur PO Plas-cCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0
Ref high
2
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like high blood pressure, kidney problems, or conditions affecting fluid balance. It can also help diagnose or monitor certain kidney-related disorders or evaluate how your kidneys respond to medications.

What Does the Test Involve?

A blood sample is taken from a vein, usually in your arm. The blood is then processed to measure renin activity in your plasma. This test does not require fasting unless specified by your healthcare provider.

What to Expect Before the Test

There are no special preparations needed for this test. However, inform your doctor about any medications you’re taking, especially those that might affect kidney function or blood pressure.

What Are Possible Results?

Results are interpreted in the context of your overall health and medical history. Abnormal levels may suggest conditions like kidney disease, certain hormonal imbalances, or other health issues affecting fluid and electrolyte balance.

Reference range

NCBI: SCC <2.0 ng/mLN/A

Specimen: plasma

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Renin Activity

Frequently asked questions

What might cause abnormal results?
High renin levels may indicate conditions such as kidney disease, certain types of hypertension (like primary aldosteronism), or conditions that cause excessive fluid loss. Low renin levels might suggest kidney damage, heart failure, or other conditions affecting fluid balance.
How often should this test be repeated?
Your doctor will determine how often you need this test based on your medical condition and treatment plan. Follow-up tests may be scheduled if your symptoms or treatment changes.
Can this test be done at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting. Home blood tests for specific analytes are not standard for renin activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy