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Renin Activity in Plasma (24-Hour Urinary Excretion)

Published: August 9, 2026Updated: August 17, 2026

This test measures how much active renin your kidneys release over 24 hours, often collected in urine. Renin plays a key role in regulating blood pressure and fluid balance.

Quick summary

["Assesses kidney function and blood pressure regulation through urinary renin levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
17516-6
Short code
Renin sup Plas-cCnc
Synonyms
Renin sup Plas-cCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Ref low
0
Ref high
2
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to evaluate kidney function, check for conditions affecting blood pressure (such as renal artery stenosis or primary aldosteronism), or monitor symptoms like high blood pressure, frequent urination, or swelling.

What to Expect Before the Test

No special preparation is needed. You’ll collect a 24-hour urine sample starting from one point in time (e.g., midnight) and finishing the next midnight. Drink plenty of fluids but avoid certain medications that may affect results (like some blood pressure drugs).

How the Test Works

Your urine is analyzed in a lab to measure the amount of active renin excreted over 24 hours. The test helps determine if your kidneys are producing enough renin or if there’s an imbalance in your body’s natural blood pressure regulation system.

Possible Results and Interpretation

Higher-than-normal levels may suggest conditions like primary aldosteronism or certain kidney diseases. Lower-than-normal levels could indicate kidney damage, certain medications, or other conditions affecting fluid balance.

Reference range

NCBI: SCC <2.0 ng/mLN/A

Specimen: plasma

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urinary Renin

Frequently asked questions

What causes abnormal urinary renin levels?
Abnormal urinary renin levels can be caused by conditions like primary aldosteronism (excessive aldosterone), renal artery stenosis (narrowing of the kidney artery), or certain kidney diseases. Medications (e.g., diuretics, ACE inhibitors) or hormonal imbalances may also affect results.
How often should I get this test?
Your doctor will determine the frequency based on your symptoms, medical history, and treatment needs. Some patients may need this test yearly or more often if managing chronic conditions like hypertension or kidney disease.
Can diet or lifestyle affect urinary renin levels?
Yes, diet and lifestyle can influence results. Avoid excessive salt intake, certain medications, and foods that may alter fluid balance (like high-sodium foods). Staying hydrated and maintaining a consistent lifestyle helps ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy